0102030405
Myristoyl Tripeptide-31 The Key Soothing Peptide In Matrixyl 3000
01
Product Description
1. MOA - Mechanism of Action
Myristoyl Tripeptide-31 is a biomimetic peptide renowned for its potent anti-inflammatory and skin-conditioning properties. Its mechanism is highly specific and plays a crucial supportive role in multi-peptide complexes.
Primary Anti-Inflammatory and Immunomodulatory Action:
*The core function of Myristoyl Tripeptide-31 is to downregulate the skin's inflammatory response. It achieves this by specifically targeting and inhibiting key pro-inflammatory cytokines, most notably Interleukin-6 (IL-6) and other mediators.
*By calming this cytokine activity, it effectively reduces skin redness, sensitivity, and the underlying inflammatory processes that can accelerate skin aging and impair barrier function.
Synergistic Role in Peptide Complexes:
*Myristoyl Tripeptide-31 is a fundamental component of the famous Palmitoyl Tetrapeptide-7 complex (as declared in INCI for ingredients like Matrixyl 3000).
*In this context, it provides the "calming foundation" that allows other collagen-stimulating peptides (like Palmitoyl Tripeptide-1) to work more effectively. By reducing background inflammation, the skin is in a more optimal state for repair and regeneration.
Barrier Support:
*Through its anti-inflammatory action, it indirectly contributes to a healthier, more resilient skin barrier, reducing reactivity and transepidermal water loss (TEWL).
The Myristoyl (C14) chain enhances the lipophilicity and skin penetration of the peptide, ensuring it reaches its target sites in the viable epidermis.
The Myristoyl (C14) chain enhances the lipophilicity and skin penetration of the peptide, ensuring it reaches its target sites in the viable epidermis.
2. In Vitro Efficacy Data
*Cytokine Inhibition Assays: In vitro studies on human cell cultures have demonstrated that the complex containing Myristoyl Tripeptide-31 can significantly reduce the secretion of IL-6 by over 50% when cells are exposed to inflammatory stimuli.
*Cell Protection: Data shows it helps protect skin cells (e.g., fibroblasts and keratinocytes) from inflammatory damage, maintaining higher cell viability and promoting a healthier cellular environment.
*Gene Expression Analysis: Molecular biology tests confirm its role in modulating the expression of genes involved in the inflammatory cascade.
3. Clinical Results
Clinical data is typically reported for the final commercial complexes (e.g., Matrixyl 3000) that feature Myristoyl Tripeptide-31 as a key ingredient.
Reduction of Irritation and Redness:
*Clinical studies on formulations with the peptide complex show a significant reduction in visible redness and stinging sensation compared to placebo.
*Dermatological assessment confirms improved skin comfort and a calmer complexion.
Enhanced Anti-Aging Efficacy:
*In studies measuring wrinkle reduction, the combination of Myristoyl Tripeptide-31 with Palmitoyl Tripeptide-1 demonstrates superior results in reducing wrinkle depth and volume compared to a single peptide, highlighting the importance of its synergistic, calming effect.
Improved Product Tolerance:
*Formulations containing this peptide are shown to be better tolerated, especially by individuals with sensitive skin, and can help mitigate the irritation potential of other active ingredients.
Safety Profile
Myristoyl Tripeptide-31 has an excellent safety profile. It is non-irritating, non-sensitizing, and exceptionally well-tolerated by all skin types.
Compatibility & Synergy
With Collagen-Stimulating Peptides (e.g., Palmitoyl Tripeptide-1): This is the classic and most powerful partnership, creating a comprehensive anti-aging solution that both repairs and soothes.
With Potent Actives (Retinol, AHAs, Vitamin C): It acts as a built-in "buffer" to reduce irritation and improve user compliance without compromising the efficacy of the actives.
With Other Soothing Agents (Niacinamide, Beta-Glucan): To create ultra-calming, barrier-repair-focused formulations.
With Hyaluronic Acid: To combine soothing with intense hydration for a plumping effect.
With Potent Actives (Retinol, AHAs, Vitamin C): It acts as a built-in "buffer" to reduce irritation and improve user compliance without compromising the efficacy of the actives.
With Other Soothing Agents (Niacinamide, Beta-Glucan): To create ultra-calming, barrier-repair-focused formulations.
With Hyaluronic Acid: To combine soothing with intense hydration for a plumping effect.
01
Recommended Dosage & Formulation
Recommended Usage Level: Typically used as part of a peptide complex at 2% to 5% in the final formulation.
Recommended Formulations:
Anti-Aging Serums & Creams: As a key component of high-performance peptide complexes.
Sensitive Skin Formulas: Specifically for calming and reducing reactivity.
Pre/Post-Procedure Care: In products designed to soothe skin after treatments like lasers or peels.
Eye Creams: To address sensitivity and fine lines in the delicate eye area.
01
The Strategic Soother
A highly targeted anti-inflammatory peptide that specifically calms the skin by inhibiting IL-6, creating an optimal environment for repair.
01
Force Multiplier in Peptide Complexes
A vital component of renowned complexes like Matrixyl 3000, where its calming action synergistically enhances the efficacy of collagen-boosting partners.
03
Enabler for Tolerable High-Performance Skincare
Allows for the formulation of more potent products with reduced risk of irritation, broadening their appeal to sensitive skin populations.
03
Clinically Validated Calming
Supported by clinical data showing visible reductions in redness and improved skin comfort.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available